Mechanism of Simvastatin on Pulmonary Hypertension Induced by High Pulmonary Blood Flow in Rats / 实用儿科临床杂志
Journal of Applied Clinical Pediatrics
; (24)2006.
Article
en Zh
| WPRIM
| ID: wpr-639277
Biblioteca responsable:
WPRO
ABSTRACT
Objective To comprehend the action mechanism of simvastatin in pulmonary hypertension(PH)when it induced by high pulmonary blood flow.Methods Abdominal aorta-inferior vena cava shunting was made in rats to establish animal model of PH induced by high pulmonary blood flow,simvastatin with dose of 2 mg/(kg?d)was used to interfere for 11 weeks.And then,pulmonary arterial pressure,apoptosis rate and proliferation rate of pulmonary vascular smooth muscle cell were determined.Results were compared with other groups.Results Simvastatin could cut down the pulmonary arterial pressure well,pulmonary arterial pressures of simvastatin group rats were lower than those of spliting groups obviously(Pa
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WPRIM
Idioma:
Zh
Revista:
Journal of Applied Clinical Pediatrics
Año:
2006
Tipo del documento:
Article