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Clinicopathological Characteristics and Predictive Markers of Early Gastric Cancer with Recurrence
Journal of Korean Medical Science ; : 1158-1164, 2009.
Artículo en Inglés | WPRIM | ID: wpr-63996
ABSTRACT
Early gastric cancer (EGC) is a "curable" disease with a high cure rate made possible through proper surgical treatment; nonetheless, some patients sustain a disease recurrence after curative resection. The aim of this study was to identify the clinicopathological characteristics of recurrent EGC and determine predictable immunohistochemical markers for recurrence. We investigated the clinicopathological features of 1,786 EGC cases, and using tissue microarray, the expression of c-erbB-2, EGFR, MLH1, MSH2, p53, and AQP1 was examined in group with recurrence and control group without recerrence. In the clinical analysis, 32 of 1,786 (1.79%) patients showed recurrence, with a 2.04% five-year cumulative recurrence rate. Age, submucosal invasion, and lymph node metastasis significantly correlated with tumor recurrence (P=0.044, 0.019, and or =57 yr) as independent risk factors of recurrence. In a case-control study, immunopositivity for c-erbB-2 was significantly associated with disease recurrence (P=0.024). There is the probability that EGC patients with old age (> or =57 yr), lymph node metastasis, submucosal invasion, and c-erbB-2 immunopositivity will experience recurrence; therefore, it is critical that patients with these risk factors be followed-up closely and considered candidates for adjuvant treatment.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pronóstico / Neoplasias Gástricas / Inmunohistoquímica / Biomarcadores de Tumor / Análisis Multivariante / Factores de Riesgo / Genes erbB-2 / Análisis por Micromatrices / Recurrencia Local de Neoplasia Tipo de estudio: Estudio de etiología / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Animales / Femenino / Humanos / Masculino Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2009 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pronóstico / Neoplasias Gástricas / Inmunohistoquímica / Biomarcadores de Tumor / Análisis Multivariante / Factores de Riesgo / Genes erbB-2 / Análisis por Micromatrices / Recurrencia Local de Neoplasia Tipo de estudio: Estudio de etiología / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Animales / Femenino / Humanos / Masculino Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2009 Tipo del documento: Artículo