Slowly Progressing Thrombotic Microangiopathy during Two Years of Treatment with Sunitinib / 대한신장학회지
Korean Journal of Nephrology
;
: 533-536, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-64073
ABSTRACT
A 75-year-old man with mild renal impairment was started on sunitinib for a metastatic gastrointestinal stromal tumor. After 7 months of this therapy, proteinuria became aggravated. Serum creatinine concentration was increased from 1.34 to 2.57 mg/dL 24 months after sunitinib administration. Hematologic features of thrombotic microangiopathy (TMA) were absent. Renal histology revealed endothelial swelling and plasmatic insudation of the glomeruli. Proteinuria and renal function improved after discontinuation of sunitinib. Our experience suggests that TMA associated with sunitinib can be diverse in onset and severity, and that the hematologic features of TMA may be absent.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Proteinuria
/
Pirroles
/
Creatinina
/
Factor A de Crecimiento Endotelial Vascular
/
Tumores del Estroma Gastrointestinal
/
Microangiopatías Trombóticas
/
Indoles
Límite:
Anciano
/
Humanos
Idioma:
Inglés
Revista:
Korean Journal of Nephrology
Año:
2011
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS