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Relationship between neuronal ?4?2 nicotinic acetylcholine receptor and neurological diseases / 上海第二医科大学学报
Journal of Shanghai Jiaotong University(Medical Science) ; (6)2006.
Artículo en Chino | WPRIM | ID: wpr-640893
ABSTRACT
Neuronal?_4?_2 nicotinic acetylcholine receptors(nAChRs) are the most widespread subtypes in central nervous system.?_4?_2 nAChRs mainly exist in procerebrum,parietal lobe cortex,temporal lobe cortex,hippocampus,basal ganglion and cerebellum.Researches on gene knock-out mice have demonstrated that?_4?_2 receptors participate in the development,aging,neuron survival,pain,and learning and memory,and are also involved in gamma-aminobutyric acid release and dopaminergic function.Studies have disclosed that?_4?_2 nAChRs relate to the development of variety of neurological diseases,including pain,Alzheimer's disease and Parkinson's disease.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Journal of Shanghai Jiaotong University(Medical Science) Año: 2006 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Journal of Shanghai Jiaotong University(Medical Science) Año: 2006 Tipo del documento: Artículo