Mutation analysis of IgVH gene in B-cell chronic lymphocytic leukemia / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences)
;
(6): 177-9, 182, 2002.
Artículo
en Inglés
| WPRIM
| ID: wpr-640945
ABSTRACT
The variable heavy chain region (VH) genes of 3 untreated patients with B-cell chronic lymphocytic leukemia (B-CLL) were cloned and analyzed. The VH family used was VH3-11, VH3-72 and VH3-33. More than 2% difference from the corresponding germline gene was detected in all the 3 obtained potential functional genes (average 16.7). Mutation pattern analysis indicated evidence of antigen selective pressure observed in 1 of 3 cases. Our findings suggested that the tumor cells originate from post-GC cells.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Región Variable de Inmunoglobulina
/
Datos de Secuencia Molecular
/
Reordenamiento Génico
/
Leucemia Linfocítica Crónica de Células B
/
Secuencia de Aminoácidos
/
Mutación
Idioma:
Inglés
Revista:
Journal of Huazhong University of Science and Technology (Medical Sciences)
Año:
2002
Tipo del documento:
Artículo
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