Effects of flavone on the oxidation-induced injury of retinal pigment epithelium cells / 国际眼科杂志(Guoji Yanke Zazhi)
International Eye Science
;
(12): 1641-1644, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-641409
ABSTRACT
AIM:
To investigate the effect of flavone on oxidation-induced injury in retinal pigment epithelium(RPE) cells.METHODS:
In in vivo studies, NaIO3-induced RPE degeneration in rat eyes were treated with 5g/L flavone eye drops 3 times a day for 1 week before and 4 weeks after NaIO3injection. At the end of 2 and 4 weeks, all rats were measured c-wave by electroretinogram(ERG). In in vitro studies,ARPE-19 cells were treated with hypoxia, H2O2, NaN3and t-BHP to induce cell damages. MTT assay was used to measure the viable cells.RESULTS:
The ERG c-wave results showed that flavone reversed NaIO3-induced injury at the end of 4 weeks. In vitro results showed flavone reversed the various oxidants-induced injuries in RPE cells.CONCLUSION:
Flavone could prevent the RPE from oxidation-induced injury both in vivo and in vitro.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
International Eye Science
Año:
2010
Tipo del documento:
Artículo
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