Effect of pan-retinal laser photocoagulation on plasma VEGF endothelin-1 and nitric oxide in PDR / 国际眼科杂志(Guoji Yanke Zazhi)
International Eye Science
;
(12): 1843-1846, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-641487
ABSTRACT
·AIM:
To study plasma levels of vascular endothelial growth factor (VEGF), endothelin-1(ET-1) and nitric oxide (NO) in patients with proliferative diabetic retino-pathy (PDR) before and after pan-retinal photocoagula-tion (PRP).·METHODS:
In this prospective study, forty patients (23 females and 17 males, mean age 48.5±12.2) with PDR without previous PRP therapy were studied. Blood samples were obtained before and 3 months after the last PRP session. Baseline (prelaser) plasma levels of VEGF, ET-1 and NO were compared with their levels in 30 healthy age- and sex- matched controls and also with plasma levels 3 months post-PRP. ·RESULTS:
Patients with PDR had significantly raised plasma VEGF (375±89ng/L), ET-1(20±5ng/L) and NO (135±53μmol/L) when compared with healthy control group (P<0.01). After PRP, there was a significant re-duction in plasma VEGF (179±66ng/L), ET-1 (11±5ng/L) and NO (91±49μmol/L) levels at 3 months' follow-up but still significantly higher than healthy controls.·CONCLUSION:
Patients with PDR demonstrate elevated VEGF, ET-1 and NO, which decreased after successful laser treatment.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio observacional
Idioma:
Chino
Revista:
International Eye Science
Año:
2009
Tipo del documento:
Artículo
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