Immunodepression during experimental Naegleria meningoencephalitis in mice
The Korean Journal of Parasitology
; : 195-198, 1987.
Article
en Ko
| WPRIM
| ID: wpr-64158
Biblioteca responsable:
WPRO
ABSTRACT
In order to test the function of lymphocytes in Naegleria fowleri-infected mice, the in vitro blastogenic response of splenocyte cultures to non-specific mitogens was studied. Concanavalin A and lipopolysaccharide stimulation were used as tests of T cell and B cell function. For the first 14 days following N. fowleri infection, lymphoblastic transformation induced by T-cell mitogen was markedly reduced in comparison to the uninfected control mice. The blastogenic response to B-cell mitogen remained depressed in the infected mice up to 14 days after infection. The fluorescent antibody titers of sera of N. fowleri infected mice were between 1:4 and 1:32. The results suggest that there is a suppression of cell mediated immunity during the acute course of experimental Naegleria meningoencephalitis in mice.
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Encéfalo
/
Linfocitos T
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Naegleria fowleri
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Alergia e Inmunología
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Meningoencefalitis
Idioma:
Ko
Revista:
The Korean Journal of Parasitology
Año:
1987
Tipo del documento:
Article