Influence of the fibroblast activity by TGF-β2 antisense oligonucleotide in corneal stroma injury of rabbit / 国际眼科杂志(Guoji Yanke Zazhi)
International Eye Science
;
(12): 291-294, 2006.
Artículo
en Chino
| WPRIM
| ID: wpr-641673
ABSTRACT
· AIM:
To investigate the influence of TGF-β 2 antisense oligonucleotide(ASON) on the differentiation, proliferation of stromal fibroblast in corneal stroma injury.both eyes of 28 rabbits, the right eyes were served as experimental group, corneal incisions were sutured with 8-0 coated vicryl suture carrying TGF-β 2 ASON; the left eyes were served as control group, corneal incision were sutured with common 8-0 coated vicryl suture. Rabbits were killed at 4, 7, 14 and 28d after surgery, stromal fibroblasts were examined by immune histochemistry and electron microscopy.significantly reduced the numbers of cells expressingα -smooth muscle actin (α -SMA) and proliferating cell nuclear antigen (PCNA). The ultrastructure of fibroblast had no significant difference in two groups.differentiation and proliferation of stromal fibroblast in corneal injury. This will be a new method to adjust corneal wound repair.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
International Eye Science
Año:
2006
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS