Cyclin dependent kinase inhibitor P27, P21 expressions in human corneal epithelium / 国际眼科杂志(Guoji Yanke Zazhi)
International Eye Science
;
(12): 745-747, 2006.
Artículo
en Chino
| WPRIM
| ID: wpr-641736
ABSTRACT
AIM:
To investigate the expressions of the cyclin dependent kinase inhibitor (CKI) in human corneal epithelium.METHODS:
The expressions of CKI, P27, P21 and proliferating cell nuclear antigen (PCNA) were tested in different regions of corneal epithelium by SP immunohistochemistry.RESULTS:
Limbal basal cells stained positively for PCNA while central corneal epithelium cells stained negatively for PCNA, their difference was statistically significant (P<0.01).Positive staining for P27 and P21 were observed in central epithelium, but there was no positive staining in limbal epithelium. Their difference were also statistically significant (P<0.01).CONCLUSION:
The different expressions of CKI P27, P21and PCNA in different corneal epithelial regions suggest that in limbal basal layer there are a group of cells that have higher proliferative capacity staying in G1 status, namely stem cell.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
International Eye Science
Año:
2006
Tipo del documento:
Artículo
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