A current survey on the selenium status and coxsakievirus B infection in Keshan disease area, Heilongjiang Province / 中国地方病学杂志

ABSTRACT

Objective To acquaint the situation of selenium nutrition level and coxsakievirus B(CVB) infection in Keshan disease(KD)patients in Heilongjiang province,and provide the evidence for taking the direction mell811rement$of KD contr01.Methods The subjeets were divided into three groupsdisease area KD group, disease area control group,and non-disease area control group.We collected soil,food and blood,which were used to detect selenium content,and assay IgN antibody of CVB in plasma.The selenium content of blood was determined with hydride generation atomic fluorometry spectrometrie.The lgM antibody of CVB was measured with ELISA test Kit.Results Compared with those in non-disease areas,selenium content of soil,maize,wheat and bean(0.092 ±0.011,0.003±0.001,0.005±0.003,0.006±0.001)μg/L in disease area Welre significantly lower(t=17.007.8.551,15.842,12.109;all P<0.01).In disease area,the levels of blood selenium in disease area KD group(34.803.±13.302)μg/L was obviously decreased compared to disease area control group(41.235±13.571) μg/L (P<0.05).The rate of CVB infection among disease area KD group,control in disease area and control in non-disease area were 90.0%,68.3%and 45.8%.The odds ratio(OR) value of CVB infected exposure between disease area and non-disease areas was 3.957,and the 95% confidence interval(CI)Was 1.898～8.246.The OR value of CVB infected exposure between KD group and control group was 4.171,with the 95%CI of 1.298～13.404.Compared with CVB non-infection group,blood selenium of CVB infection group was,lower,but not significanfly(t=1.179, P>0.05).Conclusions Selenium deficiency and CVB infection still exist in KD area,Heilongjiang Province.