A meta-analysis of therapy comparison between bimatoprost and timolol in ocular hypertention eye / 眼科研究

ABSTRACT

Objective Many researches have demonstrated the lowing-intraocular pressure(IOP) effects of bimatoprost and timolol.However,no powerful evidence showed which drug has the better efficacy.This study was to perform a meta-analysis to evaluate the efficacy and tolerability of bimatoprost compared with latanoprost in lowing IOP.MethodsThis was a evidence-based medicine science study.Pertinent studies were identified through searches of PubMed,EMBASE,the Cochrane Liberary Controlled Trials Register and Chinese Biomedicine Database using the terms of timolol,blocardren,temserin,timoptic,bimatoprost,lumigan.The intensive searching by hand and up to October 1,2008 was also designed.ResultsSix randomized and controlled studies enrolling a total of 2 094 patients were included in the meta-analysis and three clinical indexes were analyzed.Bimatoprost was associated with greater decline value from baseline IOP in comparison with timolol(P＜0.01) with a weight mean difference -2.04 at final point(95% CI-2.44 to -1.64).Numerically greater proportions of bimatoprost patients than timolol patients achieved the target IOP at 3 months(from 3 literature) and ＞6 months(from 2 literature) with a pooled RR of 1.87(95% CI1.45 to 2.41),1.60(95% CI1.36 to 1.90) (P＜0.01),respectively.Bimatoprost showed a more frequencies in the adverse effects such as conjunctival hyperemia and eyelash growth than timolol with an RR of 4.18 (95% CI2.89 to 6.05),9.40 (95% CI5.62 to 15.71).No obvious drug-related side effect was found from literature analysis included both drugs.Conclusion Searched literature offers grade A of evidences for the comparison clinical evaluation of therapy efficacy between bimatoprost and timolol in lowing IOP.Bimatoprost has a better efficacy in lowering IOP and reaching comparable proportions of patients with target IOP than timolol.Both agents are well tolerated.