Apolipoprotein E Polymorphism in Ischemic and Hemorrhagic Stroke / 대한해부학회지
Korean Journal of Anatomy
;
: 355-361, 2002.
Artículo
en Coreano
| WPRIM
| ID: wpr-643752
ABSTRACT
There is an evidence for a role of apolipoprotein E (APOE) in atherosclerosis, coronary heart disease and carotid artery stenosis. Morbidity of carotid artery atherosclerosis is higher in persons carrying an epsilon4 allele, but the association of cerebrovascular disease and apoE genotype is controversial. We studied the association between APOE genotype and allele (epsilon2, epsilon3, epsilon4) frequency and stroke. We evaluated APOE genotype in 133 first -ever stroke patients and 111 healthy controls. We also estimated the risk factors of stroke such as hypertension, diabetes and lipid profiles in both groups. APOE genotypes were analyzed by polymerase chain reaction. APOE genotypes and allele distributions were not different in patients and controls. There is also no difference of APOE allele frequencies between ischemic small artery occlusive disease and hypertensive subcortical intracerebral hemorrhage. We concluded that the APOE -epsilon4 allele is not associated with stoke including ischemic and hemorrhagic stroke.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Apolipoproteínas
/
Apolipoproteínas E
/
Arterias
/
Enfermedad de la Arteria Coronaria
/
Arterias Carótidas
/
Hemorragia Cerebral
/
Reacción en Cadena de la Polimerasa
/
Factores de Riesgo
/
Estenosis Carotídea
/
Accidente Cerebrovascular
Tipo de estudio:
Estudio de etiología
/
Factores de riesgo
Límite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Anatomy
Año:
2002
Tipo del documento:
Artículo
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