Amplication of C-myc and rearrangement of erb B2 in bladder cancer / 대한해부학회지

ABSTRACT

In order to eluciate the involvement of oncogene and tumor suprrssor gene in the tumorigenesis of human bladder tumor, I examined eleven bladder tumor tissues with Southern blot hybridization. For Southern blot c-myc, erb B2, c-fos, N-ras, K-ras, v-mos, and p53 were used as probes. In DNA analysis amplication of c-myc and rearrangement of erb B2 were detected each one case respectively. No significant alternations were obserbed in the other probes. Even though a small number of samples were examined, these finging may expect that the amplication of c-myc and the rearrangement of erb B2 play their roles in the development of bladder tumors. Futher more samples and oncogene or tumor supressor gene probes should be used to understand the tumorigenesis of the bladder cancer.