Supplementary Effect of gamma-Oryzanol on Lipid Metabolism in Diabetic KK Mice
The Korean Journal of Nutrition
;
: 347-351, 2004.
Artículo
en Coreano
| WPRIM
| ID: wpr-644560
ABSTRACT
This study was carried out to investigate the supplementary effects of gamma-oryzanol extracted from rice bran on lipid metabolism in diabetic mice. We supplied 2 kinds of experimental diets (CO without and GO with 0.2% gamma-oryzanol) to diabetic mice for 8 weeks. Diet intake, body weight, organ weight, contents of serum and hepatic lipid profiles, and fecal lipid levels were measured. Though there was no significant difference in diet intake, body weight change and organ weight between experimental groups, the concentration of serum total cholesterol and hepatic total lipid, total cholesterol and HMG-CoA reductase activity was significantly lower in GO group treated with 0.2% gamma-oryzanol of diet than CO group after supplementary period of experimental diets. And total lipid, triglyceride, total cholesterol, and bile acid levels excreted to feces were significantly higher in GO group than CO group. These results suggest that gamma-oryzanol decrease the serum and hepatic lipid levels by lowing HMG-CoA reductase activity or increasing the contents of fecal lipid in diabetic KK mice.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Tamaño de los Órganos
/
Oxidorreductasas
/
Triglicéridos
/
Bilis
/
Peso Corporal
/
Cambios en el Peso Corporal
/
Colesterol
/
Dieta
/
Metabolismo de los Lípidos
/
Heces
Límite:
Animales
Idioma:
Coreano
Revista:
The Korean Journal of Nutrition
Año:
2004
Tipo del documento:
Artículo
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