Analysis of c-Kit Gene Polymorphism in NK/T Cell Lymphoma in Korean Population / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 641-645, 2005.
Artículo
en Coreano
| WPRIM
| ID: wpr-644722
ABSTRACT
BACKGROUND AND OBJECTIVES:
The proto-oncogene c-KIT encodes a receptor tyrosine kinase (KIT) whose ligand is a stem cell factor. KIT is expressed and critical for the development and growth of mast cells, melanocytes, hematopoetic stem cells, and the interstitial cells of Cajal. In this study, c-kit gene mutations were analyzed in 27 cases of NK/T cell lymphoma. SUBJECTS ANDMETHODS:
During 1995 to 2002, 27 patients with NK/T cell lymphoma in the head and neck area were selected for this study. The nasal cavity were predominant sites (15 cases), followed by 6 nasopharynx cases, 4 tonsil 4 cases, and 2 hard palate cases. Gene mutation was analyzed by PCR-SSCP and direct sequencing.RESULTS:
c-kit gene mutation was found in 5 of 27 cases by the PCR-SSCP method. Among the 5 cases, 2 cases exhibited no mutation by direct sequencing. Consequently, the mutation of c-kit gene was detected in 3 of 27 cases.CONCLUSION:
The frequency of c-kit gene mutation (11%) indicated in the present cases is lower than that reported in north China but higher than that in Japan.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Células Madre
/
Tonsila Palatina
/
Proteínas Tirosina Quinasas
/
Proto-Oncogenes
/
Células Asesinas Naturales
/
China
/
Nasofaringe
/
Linfoma de Células T
/
Factor de Células Madre
/
Proteínas Proto-Oncogénicas c-kit
Límite:
Humanos
País/Región como asunto:
Asia
Idioma:
Coreano
Revista:
Korean Journal of Otolaryngology - Head and Neck Surgery
Año:
2005
Tipo del documento:
Artículo
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