Effect of Dietary Caseinphosphopeptide Levels on Bone Metabolism in Ovariectomized Rats
The Korean Journal of Nutrition
;
: 11-17, 2006.
Artículo
en Coreano
| WPRIM
| ID: wpr-645535
ABSTRACT
The effect of the level of casein phosphopeptide (CPP) on mineral (Ca and P) bioavailabilties and bone biomarker of aged ovariectomized (OVX) Sprague-Dawley rats were studied as a model for postmenopausal bone loss. Forty five Spargue dawley rats, 220-230g of body weight were fed a control diet (AIN 93M) or containing different level of CPP diet for 7 weeks 0% (sham control; SC, OVX control; OC), 1% (OVX low CPP diet; OL), 2% (OVX medium CPP diet; OM), 3% (OVX high CPP diet; OH) Ca absorption was unaffected by increasing CPP content from 0 to 3%. Urinary Ca excretion was increased by OVX, and decreased by CPP significantly (p<0.05) with no evident dose-relationship. The urinary P excretion was increased by CPP intake in OVX rats. The fecal excretion of P given CPP decreased in OVX with dose dependent manner. Ca and P contents of femur significantly increased by adding 2 or 3% of CPP when compared with OC group and OL group (p<0.05). There were no significant differences in serum alkaline phosphatase activity and c-terminal telopeptide excretion in experimental groups. Although ovariectomy induced the increase in urinary c-terminal telopeptide excretion, 2 or 3% of CPP in the diet decreased urinary c-terminal telopetide excretion significantly. These finding suggest the usefulness of CPP in the prevention of postmenopausal bone loss by decreasing urinary Ca excretion and bone resorption. Over 2 percent of CPP in the diet was effective to prevent postmenopausal bone loss.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fósforo
/
Peso Corporal
/
Resorción Ósea
/
Ovariectomía
/
Caseínas
/
Osteoporosis Posmenopáusica
/
Calcio
/
Ratas Sprague-Dawley
/
Dieta
/
Absorción
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
/
Femenino
/
Humanos
Idioma:
Coreano
Revista:
The Korean Journal of Nutrition
Año:
2006
Tipo del documento:
Artículo
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