The Protective Effects of Allopurinol, PAF Antagonist, LT Inhibitor, Superoxide Dismutase-Polyethylene Glycol, and Dexamethasone on Noise Induced Shift of Hearing Threshold in Guinea Pigs / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 164-167, 1999.
Artículo
en Coreano
| WPRIM
| ID: wpr-646445
ABSTRACT
BACKGROUND AND OBJECTIVES:
Prevention of noise induced hearing loss (NIHL) can be achieved by environmental control, however, recently, there are some suggestions for the protective effects of various drugs. To find an effective drug on the protection of NIHL, we investigated the protective effects of allopurinol, platelet activating factor (PAF) antagonist, leukotriene (LT) inhibitor, superoxide dismutase-polyethylene glycol (SOD-PEG), and dexamethasone on the noise induced threshold shift in guinea pigs. MAERIALS ANDMETHODS:
Thirty healthy guinea pigs (60 ears) were divided into control and different treatment groups to consist of five guinea pigs each. Guinea pigs were exposed to 100 dBA white noise for eight hours. Auditory Brainstem Response (ABR) were recorded before and after the noise exposure.RESULTS:
Changes in ABR thresholds were 48.1+/-9.6 dB SPL in the control group, 33.1+/-3.7 dB SPL in the allopurinol group, 39.37+/-17.8 dB SPL in the PAF antagonist group, 36.25+/-10.26 dB SPL in the LT inhibitor group, 38.0+/-13.98 dB SPL in the SOD-PEG group and 46.9+/-8.8 dB SPL in the dexamethasone group. Only the allopurinol group demonstrated significantly different threshold change compared to the control group.CONCLUSION:
The results of this study suggest that allopurinol may be effective in protection of noise induced threshold shift, whereas PAF antagonist, LT inhibitor, SOD, dexamethasone may not be as effective.
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Dexametasona
/
Factor de Activación Plaquetaria
/
Alopurinol
/
Potenciales Evocados Auditivos del Tronco Encefálico
/
Guinea
/
Superóxidos
/
Cobayas
/
Audición
/
Pérdida Auditiva
/
Ruido
Límite:
Animales
País/Región como asunto:
Africa
Idioma:
Coreano
Revista:
Korean Journal of Otolaryngology - Head and Neck Surgery
Año:
1999
Tipo del documento:
Artículo
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