Effects of estrogen on somatotropes in the rat pituitary culture / 대한해부학회지
Korean Journal of Anatomy
;
: 107-112, 2001.
Artículo
en Coreano
| WPRIM
| ID: wpr-646647
ABSTRACT
Although somatotropes of the pituitary gland which secret growth hormone occupy the highest percentage among pituitary hormone cells, the regulatory mechanism of the somatotropes has not been investigated as much as that of the mammotropes. The present study was performed to investigate the direct effects of estrogen on the somatotropes after estrogen treatment in culture of rat pituiary cells. Quantification of bromodeoxyuridine (BrdU)-labeled cells after double immunocytochemistry for BrdU and growth hormone (GH) or prolactin (PRL) demonstrated that estrogen treatment did not bring about the difference in either BrdU labeling index (BLI), apoptosis or cell number of somatotropes. In comparison, estrogen increased the BLI and relative cell number of mammotropes. It was suggested that the changes in the relative cell number of the somatotropes or mammotropes do not attribute to cell death, but to cell proliferation.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Hipófisis
/
Prolactina
/
Bromodesoxiuridina
/
Hormona del Crecimiento
/
Inmunohistoquímica
/
Recuento de Células
/
Muerte Celular
/
Apoptosis
/
Proliferación Celular
/
Estrógenos
Límite:
Animales
Idioma:
Coreano
Revista:
Korean Journal of Anatomy
Año:
2001
Tipo del documento:
Artículo
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