Expression and Role of Adhesion Molecules in the Nasal Mucosa of the Rat with Experimentally Induced Allergic Rhinitis / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 1514-1519, 1999.
Artículo
en Coreano
| WPRIM
| ID: wpr-647022
ABSTRACT
BACKGROUND AND OBJECTIVES:
Airway allergic reactions are induced by infiltrating inflammatory cells into the human airway tissues through interactions between vascular endothelial cells, inflammatory mediators and adhesion molecules. Accordingly, it is important to study the role of adhesion molecules for the evaluation of pathophysiology of allergy. The aim of this study is to investigate the effect of monoclonal antibodies against intercellular adhesion molecule-1 (ICAM-1) and leukocyte function associated molecule-1 (LFA-1) on the pathophysiology of allergy in ovalbumin-sensitized rats. MATERIALS ANDMETHODS:
We developed an allergy model in rat using the intraperitoneal injection and intranasal nebulization of ovalbumine solution. We evaluated in vivo effects of ICAM-1 and LFA-1 monoclonal antibodies on the expression of ICAM-1 and LFA-1 in ovalbumin sensitized rats.RESULTS:
Nasal symptoms after allergen challenge were significantly suppressed and the number of eosinophil in nasal mucosa were significantly inhibited by the treatment of adhesion molecule antibodies. Anti-ICAM-1 and anti-LFA-1 monoclonal antibodies suppressed the expression of ICAM-1 and LFA-1 in nasal mucosa of ovalbumin-sensitized rats.CONCLUSION:
It is suggested that allergy can be managed by a useful treatment method using adhesion molecule antibody.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Ovalbúmina
/
Rinitis
/
Antígeno-1 Asociado a Función de Linfocito
/
Molécula 1 de Adhesión Intercelular
/
Células Endoteliales
/
Eosinófilos
/
Hipersensibilidad
/
Inyecciones Intraperitoneales
/
Leucocitos
/
Anticuerpos
Límite:
Animales
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Otolaryngology - Head and Neck Surgery
Año:
1999
Tipo del documento:
Artículo
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