A Study of Susceptibility between Allergic Rhinitis and STAT6 Gene G2964A Polymorphism Study of a Korean Population / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
; : 868-871, 2004.
Article
en Ko
| WPRIM
| ID: wpr-647812
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND AND OBJECTIVES: T helper-type 2 cytokines, such as IL-4 and IL-13, may play a central role in allergic diseases. The proteins known as signal transducers and activators of transcription 6 (STAT-6) are key transcription factors involved in both IL-4 and IL-13 mediated biological responses. Since a polymorphism of STAT6 G2964A has been found, we investigated the association between the polymorphism of STAT6 G2964A and allergic rhinitis in Korean. SUBJECTS AND METHOD: Blood samples for genetic analysis were obtained from 229 individuals with allergic rhinitis and from 278 healthy subjects without atopic diseases. Polymerase chain reaction-based assay for the STAT6 G2964A variant was used for genotyping. RESULTS: There were no differences in the frequencies of the genotypes between the controls and patients (p>0.05). The frequencies of the STAT6 2964A allele were not statistically different between controls and allergic rhinitis patients (p>0.05). CONCLUSION: Our result suggests that the STAT6 G2964A polymorphism might not give susceptibility to the development of allergic rhinitis in Koreans.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Factores de Transcripción
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Transductores
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Rinitis
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Citocinas
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Interleucina-4
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Interleucina-13
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Pueblo Asiatico
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Alelos
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Genotipo
Límite:
Humans
Idioma:
Ko
Revista:
Korean Journal of Otolaryngology - Head and Neck Surgery
Año:
2004
Tipo del documento:
Article