Immunohistochemical Study of Nitric Oxide Synthase in Pleomorphic Adenoma of the Salivary Glands / 대한해부학회지
Korean Journal of Anatomy
;
: 107-114, 2003.
Artículo
en Inglés
| WPRIM
| ID: wpr-648449
ABSTRACT
Recent studies have suggested that nitric oxide (NO) exerts various effects on aspects of tumor biology, including angiogenesis and metastasis. There have been, however, scanty reports on nitric oxide synthase (NOS) response for tumors of the head and neck. This study was carried out to assess the distribution of both endothelial NOS (eNOS) and inducible NOS (iNOS) in normal salivary gland tissue and in pleomorphic adenoma by using immunohistochemistry. In the present study, eNOS and iNOS were higher expressed in pleomorphic adenoma than adjacent normal salivary gland tissue, suggesting that up-regulation of this enzyme is associated with tumor progression. Additionally, eNOS and iNOS expression were higher in epithelial components than in mesenchymal components. Overall, iNOS expression was higher than eNOS expression in pleomorphic adenoma. In normal tissues adjacent to pleomorphic adenoma, iNOS expression was higher in the mesenchymal type than in the epithelial type of pleomorphic adenoma. It is suggested that NO may play a role in the tumorgenesis and propagation of pleomorphic adenoma.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Glándulas Salivales
/
Biología
/
Inmunohistoquímica
/
Regulación hacia Arriba
/
Adenoma Pleomórfico
/
Óxido Nítrico Sintasa
/
Cabeza
/
Cuello
/
Metástasis de la Neoplasia
/
Óxido Nítrico
Idioma:
Inglés
Revista:
Korean Journal of Anatomy
Año:
2003
Tipo del documento:
Artículo
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