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Regulation of Mucin Exocytosis in Airway Secretory Cells / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery ; : 123-130, 2013.
Artículo en Coreano | WPRIM | ID: wpr-649324
ABSTRACT
Mucin secretion in the airway epithelium acts as an essential barrier process that protects the upper respiratory tract from inhaled particles, environmental pathogens and toxicants. However, dysregulated mucin secretion contributes to pathophysiologic conditions such as rhinitis, asthma, and chronic obstructive pulmonary disease etc. The study on mucin hypersecretion has long been worked, but the exact molecular composition and mechanism for exocytic machinery remain mostly to be elucidated. The regulated mucin secretion, highly coordinated process, is mediated by the cooperative interaction of several proteins existing in the secretory granule, cytoplasm, and plasma membrane. This review provides the information on molecular components of the core exocytic machinery and their functional roles for mucin exocytosis in airway secretory cells.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Sistema Respiratorio / Asma / Proteínas / Membrana Celular / Rinitis / Vesículas Secretoras / Enfermedad Pulmonar Obstructiva Crónica / Citoplasma / Epitelio / Exocitosis Idioma: Coreano Revista: Korean Journal of Otolaryngology - Head and Neck Surgery Año: 2013 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Sistema Respiratorio / Asma / Proteínas / Membrana Celular / Rinitis / Vesículas Secretoras / Enfermedad Pulmonar Obstructiva Crónica / Citoplasma / Epitelio / Exocitosis Idioma: Coreano Revista: Korean Journal of Otolaryngology - Head and Neck Surgery Año: 2013 Tipo del documento: Artículo