Clinical Effect of Tissue Plasminogen Activator in Vitreous Hemorrhage

ABSTRACT

There has been several reports that tissue plasminogen activator(tPA) accelerated the fibrinolysis in vitreous cavity in-vivo. We investigated the efficacy of intravitreal tPA injection(25 microgram/100 microgram, 0.1 ml) for treatment of vitreous hemorrhage in non-vitrectomized patients(58 patients, 61 eyes). 1. Visual acuity was improved in 43 eyes(70.5%) and fundus was relatively well seen in 29 eyes(47.5%). 2. There were no clinical differences of intraocular pressure between before injection and the day after injection of tPA. 3, The complication of tPA injection were rebleeding(3 eyes, 4.9%) and inflammatory reaction(1 eyes, 1.6%). On these results, it appears that intravitreal tPA injection is useful for treatment of vitreous hemorrhage before vitrectomy.