Effect of estrogen on growth hormone receptor expression of human periodontal ligament cell line / 대한치과교정학회지

ABSTRACT

The present studies were performed to investigate the interaction of 17beta-estradiol and human growth hormone(hGH) on the proliferation of human periodontal ligament(hPDL) cell. The independent effects of 17beta-estradiol and hGH on hPDL cell proliferation were investigated and the effects of hGH on hPDL cell proliferation after 17beta-estradiol pre-treatment were also investigated. Lastly, the change of hGH receptor expression in hPDL cell after 17beta-estradiol pre-treatment were investigated The obtained results were as follows; 1. The treatment of 17beta-estradiol or hGH had no significant effects on hPDL cell proliferation. 2. After pre-treatment of 17beta-estradiol, hGH stimulated the proliferation of the hPDL cell, regardless of hHG concentration. 3. Although there was not hGH receptor in the hPDL cell, hGH receptors were expressed in hPDL cell after more than 6 hours pre-treatment cf 17beta-estradiol. 4. The effect of hGH on hPDL, cell proliferation was related to the hGH receptor expression. 17beta-estradiol pre-treatment contributed to the hGH effects on the hPDL cell by stimulating hGHR expression.