Local Injection of Granulocyte-Colony Stimulating Factor Accelerates Wound Healing in a Rat Excisional Wound Model
Tissue Engineering and Regenerative Medicine
;
(6): 297-303, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-649673
ABSTRACT
A systemic treatment of granulocyte-colony stimulating factor (G-CSF) is known to improve healings of damaged tissues. However, recent studies suggested local actions of G-CSF on the healing processes of damaged tissues. We investigated the treatment effect of locally injected G-CSF and compared to that of systemically injected G-CSF in a rat model. A wound was created on the rat dorsum and treated either by local injection or by systemic injection of G-CSF. Wound healing rate, deposition of collagen, and gene expression were evaluated. G-CSF receptor (G-CSFR) protein was detected by Western blotting. The wound healing rate in the local injection group was significantly higher than that in the systemic injection group at days 9 and 15; it was also significantly higher than that in the control group at days 3, 9, and 15. The expression of G-CSFR protein in wound tissues was higher than in normal skin tissues. The local injection of G-CSF is more effective than systemic injection of G-CSF in promoting wound healing, which may implicate the local action of G-CSF treatment in wound healing processes.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Piel
/
Cicatrización de Heridas
/
Heridas y Lesiones
/
Expresión Génica
/
Western Blotting
/
Factor Estimulante de Colonias de Granulocitos
/
Colágeno
/
Receptores de Factor Estimulante de Colonias de Granulocito
/
Modelos Animales
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Tissue Engineering and Regenerative Medicine
Año:
2016
Tipo del documento:
Artículo
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