TNFalpha and TNFR2 Immunohistochemistry During Ovarian Follicular Development and Atresia in the Rat / 대한해부학회지
Korean Journal of Anatomy
; : 553-559, 2005.
Article
en En
| WPRIM
| ID: wpr-650358
Biblioteca responsable:
WPRO
ABSTRACT
Tumor necrosis factor alpha (TNFalpha) is an intraovarian cytokine that may play a role in ovarian development and function. Identification of ovarian TNFalpha receptors provides support for establishing a role of TNFalpha in ovarian development and function. TNFalpha exerts its effects by binding to either TNF receptor 1 or 2 (TNFR1 or TNFR2). When TNFalpha binds with TNFR2, expression of survival genes is up-regulated, resulting in proliferation of granulosa cells. In the present study, the authors identified the changes in localization of TNFalpha and the expression of TNFR2 in granulosa cells during follicular atresia in rat ovaries. In healthy follicles, intense signals for TNFalpha and TNFR2 were found in the outer surface of the granulosa layer, where many proliferating cells and no apoptotic cells were observed. In atretic follicles, decreased expression of TNFalpha and TNFR2 was observed in the granulosa layer, where many apoptotic cells were seen. These findings suggested that TNFalpha acts as a survival factor in granulosa cells during follicular atresia in rat ovaries.
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Texto completo:
1
Índice:
WPRIM
Asunto principal:
Ovario
/
Inmunohistoquímica
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Factor de Necrosis Tumoral alfa
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Apoptosis
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Receptores del Factor de Necrosis Tumoral
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Receptores Tipo II del Factor de Necrosis Tumoral
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Atresia Folicular
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Folículo Ovárico
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Células de la Granulosa
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Korean Journal of Anatomy
Año:
2005
Tipo del documento:
Article