Altered Expression of Metabotropic Glutamate Receptors mGluR1, mGluR5, and mGluR2/3 in the Diabetic Rat Retina / 대한해부학회지
Korean Journal of Anatomy
;
: 491-498, 2003.
Artículo
en Coreano
| WPRIM
| ID: wpr-650728
ABSTRACT
An excitatory neurotransmitter glutamate is engaged in slow transmission by activating the secondary signal transduction pathway through metabotropic receptors of the target cells. The present study has been investigated the localization of group I (mGluR1 and mGluR5) and II (mGluR2/3) metabotropic glutamate receptors in the retina and their altered expression patterns following long-term diabetes using immunohistochemistry, in order to clarify the involvement of the slow transmission of glutamate in diabetic retinopathy. Insulin-dependent diabetes was induced by a single intravenous injection of streptozotocin. Experimental periods were set at 1, 4, 12 and 24 weeks after the onset of diabetes. MGluR1 and mGluR5 were expressed in the outer plexiform layer, 1, 3, and 5 strata of the inner plexiform layer, and the photoreceptor layer in the retina at normal state. In the early periods of diabetes, the expression pattern of group I receptors was no large change. The expression level in the photoreceptor layer of 12 and 24 weeks diabetic retinas was increased, while that in the IPL was decreased. MGluR2/3 was expressed in the amacrine cells, in the displaced amacrine cells, and in two bands in the inner plexiform layer at normal retina. In later diabetic periods, the expression level of mGluR2/3 was increased in the two bands especially. These results demonstrate that diabetes induces the activation of I and II mGluRs in the retina, and may suggest the involvement of slow transmission of glutamate via metabotropic receptors in progression of diabetic retinopathy.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Retina
/
Inmunohistoquímica
/
Transducción de Señal
/
Estreptozocina
/
Receptores de Glutamato Metabotrópico
/
Neurotransmisores
/
Ácido Glutámico
/
Células Amacrinas
/
Retinopatía Diabética
/
Inyecciones Intravenosas
Límite:
Animales
Idioma:
Coreano
Revista:
Korean Journal of Anatomy
Año:
2003
Tipo del documento:
Artículo
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