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Pathogenetic Hypothesis of Benign Laryangeal Disease from Histopathologic Change in the Basement Membrane Zone and the Superficial Layer of Lamina Propria / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery ; : 65-69, 2005.
Artículo en Coreano | WPRIM | ID: wpr-650871
ABSTRACT
BACKGROUND AND

OBJECTIVES:

The epithelium, basement membrane zone (BMZ) and superficial layer of lamina propria (SLLP) in the vocal fold possess similar mechanical properties and behave as one single tissue, which is commonly referred to as the "cover". The purpose of this study is to elucidate the ultra structural and histopathological changes and differences in the cover of benign laryngeal lesions, and also to investigate the pathogenetic response. MATERIALS AND

METHOD:

The cover of the vocal fold in vocal nodule, polyp and Reinke's edema was investigated on 87 patients. Immunohistochemical analysis was performed with monoclonal antibodies directed against collagen type III and VII for identification of SLLP and anchoring fiber. Control specimens were obtained from 10 uninvolved side vocal fold in the laryngeal specimen after total laryngectomy.

RESULTS:

One type of injury in the cover was due to a little or no change of SLLP, which was seen more often in vocal nodules. The second type of pathologic finding shows disorganized anchoring fiber and extensive interstitial injury, which was seen more often in vocal polyp. The third type shows injury in the anchoring fiber and sparse distribution of collagen type III in SLLP, which was the main finding in Reinka's edema. These findings lead us to understand the pathogenesis of the disease that developed as different entities.

CONCLUSION:

We conclude that collagens in BMZ and SLLP are the structures that seem to provide the pathogenetic portion of benign laryngeal diseases which develop from the same phonotrauma into clinically different disease entities.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pólipos / Membrana Basal / Pliegues Vocales / Enfermedades de la Laringe / Colágeno / Colágeno Tipo III / Edema / Epitelio / Laringectomía / Anticuerpos Monoclonales Tipo de estudio: Estudio pronóstico Límite: Humanos Idioma: Coreano Revista: Korean Journal of Otolaryngology - Head and Neck Surgery Año: 2005 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pólipos / Membrana Basal / Pliegues Vocales / Enfermedades de la Laringe / Colágeno / Colágeno Tipo III / Edema / Epitelio / Laringectomía / Anticuerpos Monoclonales Tipo de estudio: Estudio pronóstico Límite: Humanos Idioma: Coreano Revista: Korean Journal of Otolaryngology - Head and Neck Surgery Año: 2005 Tipo del documento: Artículo