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A Interventional Study in a Real Life Setting to Assess the Clinical Efficacy and Effect on Fracture in the 1 Year after Injection of Zoledronic Acid in Osteoporotic Patients with Long Bone or Spine, Pelvic Fractures / 대한정형외과학회잡지
The Journal of the Korean Orthopaedic Association ; : 320-326, 2016.
Artículo en Coreano | WPRIM | ID: wpr-651022
ABSTRACT

PURPOSE:

We studied the improvement of back pain in vertebral fracture and fracture healing in non-vertebral fracture after treatment with zoledronate in postmenopausal patients. MATERIALS AND

METHODS:

Postmenopausal women with bone mineral density (BMD) T-score of -2.5 or less and existing vertebral fractures or non-vertebral fractures between January 2011 and June 2012 were included. Patients received a single intravenous infusion of zoledronate within 3 days after diagnosis of fractures. The primary outcome was BMD and secondary outcomes were visual analogue scale (VAS) for back pain, fracture healing, and new clinical fracture.

RESULTS:

T-score increased significantly in the vertebral fracture group (n=97) and non-vertebral fracture group (n=31) at 1 year (p<0.05). The average VAS for back pain decreased significantly in the vertebral fracture group (p<0.05) and there was no delayed union, nonunion in the non-vertebral fracture group. There was no re-fracture and 3 new clinical fractures (2.34%) occurred during the follow-up period.

CONCLUSION:

Zoledronate, as treatment in postmenopausal osteoporosis patients can improve BMD, reduce back pain in vertebral fracture, and has no negative effect on bone healing after fracture in non-vertebral fracture.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Osteoporosis / Columna Vertebral / Infusiones Intravenosas / Densidad Ósea / Osteoporosis Posmenopáusica / Estudios de Seguimiento / Resultado del Tratamiento / Curación de Fractura / Dolor de Espalda / Diagnóstico Tipo de estudio: Estudio diagnóstico / Estudio observacional / Estudio pronóstico Límite: Femenino / Humanos Idioma: Coreano Revista: The Journal of the Korean Orthopaedic Association Año: 2016 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Osteoporosis / Columna Vertebral / Infusiones Intravenosas / Densidad Ósea / Osteoporosis Posmenopáusica / Estudios de Seguimiento / Resultado del Tratamiento / Curación de Fractura / Dolor de Espalda / Diagnóstico Tipo de estudio: Estudio diagnóstico / Estudio observacional / Estudio pronóstico Límite: Femenino / Humanos Idioma: Coreano Revista: The Journal of the Korean Orthopaedic Association Año: 2016 Tipo del documento: Artículo