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Use of Nonhuman Primates for the Development of Bioengineered Female Reproductive Organs
Tissue Engineering and Regenerative Medicine ; (6): 323-334, 2016.
Artículo en Inglés | WPRIM | ID: wpr-651506
ABSTRACT
Nonhuman primates (NHPs) have been widely used in reproductive biology, neuroscience, and drug development since a number of primate species are phylogenetically close to humans. In this review, we summarize the use of NHPs for nonclinical application in the reproductive system disorders including the loss or failure of an organ or tissue. Causes of infertility include congenital aplasia and acquired disorders of the reproductive organs. In addition, anti-cancer treatments can deplete ovarian follicles, leading to premature ovarian failure, infertility and long-term health risks. Along with a limited supply of human reproductive organs, anatomic/physiologic similarities to humans support the need for NHP models (New-World monkeys such as the common marmoset and Old-World monkeys such as cynomolgus and rhesus monkeys) to promote the advances in female infertility studies. For maintaining and executing animal studies using NHP, special protocols including animal care, anesthetic protocol, surgical technique, and immunosuppressive protocol are necessary. With a growing interest in the potential therapies such as endometrial tissue engineering, and ovary/follicle cryopreservation and grafting in Korea, this review can be useful in selecting appropriate animal models and can bridge between nonclinical studies and clinical applications by providing detailed information on the use of NHPs in the field of reproductive organ disorders.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Primates / Trasplante / Biología / Neurociencias / Callithrix / Criopreservación / Insuficiencia Ovárica Primaria / Haplorrinos / Trasplantes / Modelos Animales Tipo de estudio: Guía de Práctica Clínica Límite: Animales / Femenino / Humanos País/Región como asunto: Asia Idioma: Inglés Revista: Tissue Engineering and Regenerative Medicine Año: 2016 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Primates / Trasplante / Biología / Neurociencias / Callithrix / Criopreservación / Insuficiencia Ovárica Primaria / Haplorrinos / Trasplantes / Modelos Animales Tipo de estudio: Guía de Práctica Clínica Límite: Animales / Femenino / Humanos País/Región como asunto: Asia Idioma: Inglés Revista: Tissue Engineering and Regenerative Medicine Año: 2016 Tipo del documento: Artículo