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Tissue distribution of sialic acid-linked influenza virus receptors in beagle dogs
Journal of Veterinary Science ; : 219-222, 2012.
Artículo en Inglés | WPRIM | ID: wpr-65173
ABSTRACT
Reports of influenza A virus infections in dogs has received considerable attention from veterinarians, virologists, and epidemiologists. Interaction between influenza viral hemagglutinin and cell oligosaccharides containing sialic acid residues results in infection. Sialic acids have an alpha-2,3-linkage to the penultimate galactose in the avian influenza virus receptor and an alpha-2,6-linkage in the human receptor. To date, there are no detailed data on the tissue distribution or histological features of either type of sialic acid-linked influenza virus receptors in beagle dogs, which are common laboratory animals and pets. We conducted the current study to visualize the in situ tissue distribution of both sialic acid-linked influenza virus receptors in various organs of beagle dogs using Maackia amurensis lectin II and Sambucus nigra agglutinin. Both alpha-2,3- and alpha-2,6-sialic acid-linked receptors were detected in the endothelial cells of the respiratory tract and other organs. Endothelial cells of most gastrointestinal organs were negative for alpha-2,3-sialic acid-linked receptors in the dogs. Our results suggested that these canine organs may be affected by influenza virus infection. The findings from our study will also help evaluate the occurrence and development of influenza virus infections in dogs.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Especificidad de Órganos / Receptores Virales / Infecciones por Orthomyxoviridae / Receptores de Superficie Celular / Ácido N-Acetilneuramínico / Sambucus nigra / Maackia / Lectinas de Plantas / Enfermedades de los Perros / Perros Límite: Animales Idioma: Inglés Revista: Journal of Veterinary Science Año: 2012 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Especificidad de Órganos / Receptores Virales / Infecciones por Orthomyxoviridae / Receptores de Superficie Celular / Ácido N-Acetilneuramínico / Sambucus nigra / Maackia / Lectinas de Plantas / Enfermedades de los Perros / Perros Límite: Animales Idioma: Inglés Revista: Journal of Veterinary Science Año: 2012 Tipo del documento: Artículo