Effect of Cyanidin on Cell Motility and Invasion in MDA-MB-231 Human Breast Cancer Cells
The Korean Journal of Nutrition
;
: 711-717, 2008.
Artículo
en Coreano
| WPRIM
| ID: wpr-652669
ABSTRACT
Anthocyanidins, the aglycones of anthocyanins, are natural colorants belonging to the flavonoid family. Cyanidin is one of the anthocyanidins, used for their antioxidant properties. Furthermore, previous studies have shown anthocyanidin-rich material extracts or aglycone form inhibit growth and induce apoptosis of cancer cells. But, Tumor metastasis is the most important cause of cancer death, and various treatment strategies have targeted on preventing the occurrence of metastasis. This study investigated the effects of cyanidin on metastasis processes, including motility, invasion and activity of MMP-2 and MMP-9 in MDA-MB-231 human breast cancer cell lines. We cultured MDA-MB-231 cells in presence of various concentrations 0, 5, 10 and 20 micrometer of cyanidin. The cell motility was significantly decreased dosedependently in cells treated with cyanidin (p < 0.05) and cyanidin treatment caused the significant suppression of the invasion (p < 0.05). MMP-2 and MMP-9 activities, and MMP-9 mRNA express were not affected by anthocyanin treatment. In conclusion, cyanidin inhibits cell motility, invasion in MDA-MB-231 human breast cancer cell lines.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Mama
/
Neoplasias de la Mama
/
ARN Mensajero
/
Línea Celular
/
Movimiento Celular
/
Apoptosis
/
Antocianinas
/
Metástasis de la Neoplasia
Límite:
Humanos
Idioma:
Coreano
Revista:
The Korean Journal of Nutrition
Año:
2008
Tipo del documento:
Artículo
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