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Neuroprotection for Acute Spinal Cord Injury: Comparison of Simvastatin and Atorvastatin / 대한정형외과학회잡지
The Journal of the Korean Orthopaedic Association ; : 551-559, 2008.
Artículo en Coreano | WPRIM | ID: wpr-653903
ABSTRACT

PURPOSE:

To evaluate the neuroprotective effect of statins after a spinal cord injury. MATERIALS AND

METHODS:

Twenty four Sprague Dawley rats had a spinal cord injury at T9/10 using an Ohio State University (OSU) impactor. The animals were randomized to receive either simvastatin, atorvastatin, or saline with oral gavage everyday for 7 days. A behavioral outcome assessment was performed on days 2, 4 and 7, and then every week using the Basso, Bresnahan, and Beattie (BBB) score and subscore. The animals also underwent sensory threshold testing using a von Frey monofilament device. The animals were sacrificed at the end of 6 weeks and a spinal cord specimen was harvested. Histology and immunohistochemistry were performed to measure the areas of white and gray matter, and the sparing of oligodenrocytes.

RESULTS:

For the animals treated with simvastatin, atorvastatin and saline, the mean BBB scores at 6 weeks post-injury was 13.2+/-0.1, 11.8+/-0.5, and 11.3+/-0.2 and the BBB subscores were 9.2+/-1.1, 4.8+/-1.8 and 4.4+/-1.4 respectively (p<0.05). The areas of white matter at the lesion epicenter were 0.78+/-0.05, 0.5+/-0.18 and 0.41+/-0.03 mm2 in the simvastatin, atorvastatin and saline groups respectively, and the number of spared oligodendrocytes was significantly higher in the simvastatin treated animals (p<0.05).

CONCLUSION:

The simvastatin treatment improved the behavior and histological sparing of the spinal cord after an acute spinal cord injury in rats.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pirroles / Umbral Sensorial / Médula Espinal / Traumatismos de la Médula Espinal / Inmunohistoquímica / Ohio / Oligodendroglía / Ratas Sprague-Dawley / Fármacos Neuroprotectores / Simvastatina Tipo de estudio: Ensayo Clínico Controlado Límite: Animales / Humanos País/Región como asunto: America del Norte Idioma: Coreano Revista: The Journal of the Korean Orthopaedic Association Año: 2008 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pirroles / Umbral Sensorial / Médula Espinal / Traumatismos de la Médula Espinal / Inmunohistoquímica / Ohio / Oligodendroglía / Ratas Sprague-Dawley / Fármacos Neuroprotectores / Simvastatina Tipo de estudio: Ensayo Clínico Controlado Límite: Animales / Humanos País/Región como asunto: America del Norte Idioma: Coreano Revista: The Journal of the Korean Orthopaedic Association Año: 2008 Tipo del documento: Artículo