Efficacy of Benzodiazepines to Laryngopharyngeal Reflux: A Double-Blind, Randomized Controlled Study / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 1267-1270, 2005.
Artículo
en Coreano
| WPRIM
| ID: wpr-653938
ABSTRACT
BACKGROUND AND OBJECTIVES:
Anti-anxiety drugs such as benzodiazepines are often given to globus patients in practice, based on the notion that globus is a kind of somatization disorder. However, many of globus are caused by laryngopharyngeal reflux (LPR) and the effects of anti-anxiety drugs to LPR are unknown. The study goal was to assess the efficacy of benzodiazepines to LPR. SUBJECTS ANDMETHOD:
We selected 51 LPR patients, who were confirmed by 24-hour double-probe ambulatory pH monitoring. Patients were allocated into case and control groups at random and entered into a double-blind trial. Patients in the control group received proton pump inhibitors and prokinetics. Diazepam was added to patients in the case group. Assessments were made after 4 weeks of treatment using reflux symptom index (RSI) and reflux finding score (RFS).RESULTS:
In both groups, RSI and RFS were improved significantly at the end of the study. However, there was no significant difference between the two groups.CONCLUSION:
Diazepam seems to have little efficacy in the treatment of LPR.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Trastornos Somatomorfos
/
Ansiolíticos
/
Benzodiazepinas
/
Reflujo Gastroesofágico
/
Trastornos de Conversión
/
Diazepam
/
Inhibidores de la Bomba de Protones
/
Reflujo Laringofaríngeo
/
Concentración de Iones de Hidrógeno
Tipo de estudio:
Ensayo Clínico Controlado
Límite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Otolaryngology - Head and Neck Surgery
Año:
2005
Tipo del documento:
Artículo
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