The Mechanism of Methacholine Induced Ciliostimulation: The Relationship with Cyclooxygenase Pathway and Nitric Oxide / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 517-521, 2006.
Artículo
en Coreano
| WPRIM
| ID: wpr-654525
ABSTRACT
BACKGROUND AND OBJECTIVES:
Mucociliary movement of respiratory ciliated epithelium is one of important protective mechanisms in the upper respiratory airway. It is well known that methacholine induces a ciliostimulation. This study designed to investigate the regulatory mechanism of methacholine induced ciliostimulation. MATERIALS ANDMETHOD:
We investigated in vitro effect of methacholine, a beta-methyl ester of acetylcholine, and nitric oxide on ciliary beat frequency (CBF) of nasal septal mucosa of SD rat. CBF was measured using a video computerized analysis system.RESULTS:
Methacholine (10(-6) mol/L) increased CBF upto 6 hours with a maximum increase of 44%. Diclofenac inhibited the ciliostimulatory effect of methacholine completely. LNAME inhibited the increase in CBF by methacholine significantly (p<.05).CONCLUSION:
The results suggest that ciliostimulatory effects by methacholine in airway epithelium involves prostaglandin pathway and may be regulated by nitric oxide.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Acetilcolina
/
Diclofenaco
/
Depuración Mucociliar
/
Cloruro de Metacolina
/
Prostaglandina-Endoperóxido Sintasas
/
Epitelio
/
Membrana Mucosa
/
Óxido Nítrico
Límite:
Animales
Idioma:
Coreano
Revista:
Korean Journal of Otolaryngology - Head and Neck Surgery
Año:
2006
Tipo del documento:
Artículo
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