Expression of the biological marker PCNA in breast carcinoma

ABSTRACT

The study determined the expression of the biological marker PCNA in invasive breast carcinoma patients treated at Oncology Hospital and HCMC Medical and Pharmaceutical University Hospital from January 2003 to January 2004. The results found out the correlation of the marker with the basic prognostic factors such as age of patients, histopathological features, histological grade, and lymph node metastases. Among 371 specimens of invasive breast carcinoma which were stained with immunohistochemical technique, there were 96.2% specimens have had the overexpression of PCNA in the cancer cells. However, there was not relation between the overexpression of PCNA and the basic prognostic factors, therefore, it is not necessary to find out the expression of PCNA in all cases of invasive breast carcinoma