Effect of Platelet Rich Plasma on Facial Nerve Regeneration in Acute Nerve Injury Model / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 486-491, 2009.
Artículo
en Coreano
| WPRIM
| ID: wpr-655556
ABSTRACT
BACKGROUND AND OBJECTIVES:
The object of this study was to evaluate the effect of platelet rich plasma (PRP) on facial nerve regeneration from an axotomy injury in the guinea pig model. MATERIALS ANDMETHOD:
Experiments involved the transection and repair of right facial nerve. The right facial nerve of 14 albino guinea pigs were completely transected and immediately sutured, followed by fibrin glue only (control group) or fibrin glue +PRP (PRP group). Western blot assay was used to detect neurotrophic factors secreted by PRP. Nerve regeneration was assessed by motor function, electrophysiology, and histology studies.RESULTS:
High levels of neurotrophin-3, angiopoietin-1, glial cell line derived neurotrophic factors, nerve growth factors and brain derived neurotrophic factors were demonstrated in PRP. Motor function recovery, compound motor action potentials, and axon count showed significant improvement in guinea pig treated with PRP.CONCLUSION:
There was an improved functional outcome with the use of PRP in comparison with control. The increased nerve regeneration found in this study may be due to the neurotrophic factors secreted by PRP.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Regeneración
/
Axones
/
Plaquetas
/
Potenciales de Acción
/
Adhesivo de Tejido de Fibrina
/
Western Blotting
/
Factor Neurotrófico Derivado del Encéfalo
/
Axotomía
/
Recuperación de la Función
/
Factor de Crecimiento Nervioso
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Coreano
Revista:
Korean Journal of Otolaryngology - Head and Neck Surgery
Año:
2009
Tipo del documento:
Artículo
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