Analysis of Microsatellite Instability and Loss of Heterozygosity in Sporadic Keratoacanthoma / 대한해부학회지
Korean Journal of Anatomy
;
: 55-61, 2005.
Artículo
en Coreano
| WPRIM
| ID: wpr-655576
ABSTRACT
Tumors from patients with hereditary non-polyposis colorectal cancer (HNPCC)and from a subset of patients with the related Muir-Torre syndrome exhibit a type of a genetic instability, known as microsatellite instability (MIS), which results from mutations that inactivate DNA mismatch repair genes. Keratoacanthomas resemble squamous cell carcinoma but after a period of rapid growth over a few months they involute completely. The detection of MIS in a keratoacanthoma from a patient with Muir-Torre syndrome suggested that defective mismatch repair genes may play a role in the pathogenesis of these neoplasmas. In order to elucidate the significance of both MIS and loss of heterozygosity (LOH)in the pathogenesis of sporadic keratoacanthomas, the presents of MIS and LOH at 11 microsatellite markers (D2S286, D2S367, D3S1317, D5S346, D9S16, D9S171, D10S89, D10S185, D11S904, D17S261, and D17S520) were evaluated in randomly selected sporadic keratoacanthomas. MIS and LOH were found only in 1 of 10 cases at D17S261 and D10S185, respectively. In conclusion, the low frequency of MIS and LOH detected in this study suggests that neither MIS nor LOH appear to be significant in the induction of sporadic keratoacanthomas.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Carcinoma de Células Escamosas
/
Neoplasias Colorrectales
/
Repeticiones de Microsatélite
/
Pérdida de Heterocigocidad
/
Inestabilidad de Microsatélites
/
Reparación de la Incompatibilidad de ADN
/
Síndrome de Muir-Torre
/
Queratoacantoma
Límite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Anatomy
Año:
2005
Tipo del documento:
Artículo
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