The Morphological Studies on the Effects of Nerve Growth Factor on the Schwann Cell in the Diabetic Neuropathy in the Rats / 대한해부학회지
Korean Journal of Anatomy
;
: 723-731, 2000.
Artículo
en Coreano
| WPRIM
| ID: wpr-656865
ABSTRACT
Diabetic neuropathy is a broad term that encompasses many destructive syndromes that various kinds of neuronal population is affected in diabetes mellitus. Diabetic neuropathy has been postulated to occur by diverse pathogenetic mechanisms. Recent studies suggest that the reduction of neurotrophic factors is one of the causes of diabetic neuropathy. This study was performed to identify the effect of nerve growth factor on Schwann cell in the streptozotocin-induced diabetic rats morphologically. Sprague-Dawley rats (weighed about 200 gm) were rendered diabetes by injection of streptozotocin (STZ 65 mg/kg) and nerve growth factor was administered for 4 weeks. The result obtained are as followed 1. Degenerations in cytoplasmic organelles of Schwann cell of the myelinated nerve fibers in diabetic rats were identified. 2. Degenerations in cytoplasmic organelles of the Schwann cell of the unmyelinated nerve fibers in diabetic rats were identified and abnormal axons were appeared. 3. Nerve growth factor had an effect on the recovery of degeneration and it was more effective in myelinated nerve fibers. These results suggest that early administration of nerve growth factor have the effect of protection of diabetic neuropathy by morphological study.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Axones
/
Orgánulos
/
Ratas Sprague-Dawley
/
Estreptozocina
/
Factor de Crecimiento Nervioso
/
Citoplasma
/
Fibras Nerviosas Amielínicas
/
Diabetes Mellitus
/
Neuropatías Diabéticas
/
Fibras Nerviosas Mielínicas
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Coreano
Revista:
Korean Journal of Anatomy
Año:
2000
Tipo del documento:
Artículo
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