Comparison of the Tuberculin Skin Test and the Interferon-gamma Release Assay for the Diagnosis of Cervical Tuberculous Lymphadenitis / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 354-358, 2013.
Artículo
en Coreano
| WPRIM
| ID: wpr-657020
ABSTRACT
BACKGROUND AND OBJECTIVES:
To compare the tuberculin skin test (TST) and the interferon gamma release assay (IGRA) for the diagnosis of cervical tuberculous lymphadenitis (TL). SUBJECTS ANDMETHOD:
A prospective comparison between the TST and the IGRA was performed in subjects who met the inclusion criteria for suspicious cervical TL. TL was confirmed by culture results and clinical diagnosis of TL was also made by histology, polymerase chain reaction and treatment response of the anti-tuberculosis drug.RESULTS:
Of the 43 subjects enrolled, 11 subjects were confirmed as TL, nine subjects as clinical TL and 23 subjects as non-TL. The TST and the IGRA were all positive in TL. The agreement between the TST and IGRA was kappa=0.40 in both clinical TL and non-TL. The sensitivity and specificity of the TST were 95.0% [95% confidence interval (CI), 92.1-97.9] and 39.1% (95% CI, 32.6-45.6), respectively. By comparison, the sensitivity and specificity of the IGRA were 85.0% (95% CI, 80.3-89.8) and 52.2% (95% CI, 45.5-58.8), respectively.CONCLUSION:
The IGRA was more specific than the TST, while the TST was more sensitive than the IGRA. The higher specificity of IGRA could make IGRA play a useful adjunct role in the diagnosis for cervical TL.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Piel
/
Tuberculina
/
Tuberculosis
/
Tuberculosis Ganglionar
/
Pruebas Cutáneas
/
Reacción en Cadena de la Polimerasa
/
Estudios Prospectivos
/
Sensibilidad y Especificidad
/
Interferones
/
Interferón gamma
Tipo de estudio:
Estudio diagnóstico
/
Estudio observacional
Idioma:
Coreano
Revista:
Korean Journal of Otolaryngology - Head and Neck Surgery
Año:
2013
Tipo del documento:
Artículo
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