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The Effects of (66)Ho-Loaded Radioactive Stent in a Porcine Model
Korean Circulation Journal ; : 479-484, 2002.
Artículo en Coreano | WPRIM | ID: wpr-65746
ABSTRACT
BACKGROUND AND

OBJECTIVES:

Vascular brachytherpy known to be an effective method in the prevention of restenosis following percutaneous coronary intervention (PCI). In this study we observed the effects of a radioisotope-loaded stent in a porcine model. MATERIALS AND

METHODS:

Holmium-166 ((166)Ho) was loaded onto the stent surface using impregnated polyurethane, and placed the stents into 7 porcine coronary arteries. Four weeks after stent overdilation injury, histopathological examination was performed.

RESULTS:

The absorbed dose of (166)Ho to the coronary artery, from the 158.5+/-140.9 microCi (166)Ho stent, was about 141 Gy at a depth of 0.5 mm, which was calculated by Monte Carlo EGS 4 Code. The mean external, and internal elastic lamina areas, the luminal and neointimal areas and the histopathological area stenosis in the 7 porcine coronary arteries were 7.6+/-2.8 mm2, 4.7+/-1.6 mm2, 2.4+/-1.4 mm2, 2.3+/-1.6 mm2 and 49.4+/-24.9%, respectively. The histopathological findings revealed remarkable inflammatory reactions and thrombosis in two of the porcine coronary arteries.

CONCLUSION:

(166)Ho radioactive loaded stents, using impregnated polyurethane, may inhibit neointimal hyperplasia, but the problems of stent thrombosis and inflammation should be solved.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fenobarbital / Poliuretanos / Radioisótopos / Trombosis / Stents / Constricción Patológica / Vasos Coronarios / Reestenosis Coronaria / Intervención Coronaria Percutánea / Hiperplasia Idioma: Coreano Revista: Korean Circulation Journal Año: 2002 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fenobarbital / Poliuretanos / Radioisótopos / Trombosis / Stents / Constricción Patológica / Vasos Coronarios / Reestenosis Coronaria / Intervención Coronaria Percutánea / Hiperplasia Idioma: Coreano Revista: Korean Circulation Journal Año: 2002 Tipo del documento: Artículo