Clinical observation of long - term effect of antipsychotics on electrocardiogram QTc / 中国生化药物杂志

ABSTRACT

Objective To explore the clinical effect of long-term use of antipsychotic drugs on electrocardiogram QTc. Methods A total of 100 patients with schizophrenia were enrolled from May 22, 2016 to May 22, 2017, and antipsychotics were treated. Of the 26 patients, haloperidol was treated with haloperidol and 34 patients were treated with chlorine Propoxazine treatment, 19 patients were treated with sulpiride, 21 patients were treated with perphenazine, followed by analysis of different drugs after treatment of ECG changes, before and after treatment QT / QTc interval>400 ms incidence. Results QT was (376.36 ± 12.18) ms and QTc was (414.96 ± 14.56) ms after haloperidol treatment, and the QT was (378.15 ± 15.43) ms and the QTc was (407.36 ± 12.75) ms after perphenazine treatment; After treatment, QT was (382.15 ± 13.85) ms and QTc was (401.86 ± 15.86) ms. QT was (382.12 ± 13.24) ms and QTc was (396.35 ± 12.05) ms after chlorpromazine treatment. (P <0.05). The QT / QTc interval was more than 400 hours after treatment (P <0.05). The incidence of QT / QTc interval> 400ms after haloperidol treatment was higher than that before treatment (P <0.05), chlorpromazine, sulpiride, There was no difference in the rate . Conclusion Long-term use of antipsychotic drugs can affect the ECG QTc.