Clinical study of two routes of vancomycin assisted continuous drainage in the treatment of secondary intracranial infection after traumatic brain injury / 中国生化药物杂志

ABSTRACT

Objective To investigate the clinical effect of continuous infusion of vancomycin in the treatment of intracranial infection secondary to traumatic brain injury by intrathecal injection and intravenous infusion. Methods 96 patients with traumatic brain injury from December 2015 to March 2017 were randomly divided into study group and control group, the patients were randomly divided into study group and control group (n=48).The study group of patients with continuous drainage combined with vancomycin intrathecal injection treatment, the control group of patients with continuous drainage combined with vancomycin intravenous infusion. The clinical effects of two groups of patients with secondary intracranial infection after traumatic brain injury were recorded. Results After treatment, the total effective rate of clinical treatment in the study group was as high as 89.58%, compared with 70.83% in the control group, the differences were statistically significant(P<0.05). Conclusion Vancomycin intrathecal injection combined with continuous drainage is effective in the treatment of secondary intracranial infection after brain injury, and it is beneficial to protect the quality of life and life safety of the patients.