Water decoction of Platycladus orientalis reduces blood glucose and lipids in mice / 中国病理生理杂志

ABSTRACT

AIM:To study the effects of water decoction of Platycladus orientalis on reducing high blood glucose and lipids in diabetic and hyperlipidemia nice,respectively.METHODS:The mouse model of hyperlipidemia was established.The increasing rate of weight, hepatic index, lipid content of liver and atherosclerosis index (AI) were meas-ured.Blood levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), adiponec-tin (ADP) and interleukin-6 (IL-6) were detected.According to these indexes, the function of water decoction of Platy-cladus orientalis for reducing high blood lipids caused by hyperlipidemia was evaluated .At the same time, the model of dia-betes mellitus was established .The levels of fasting plasma glucose , fasting plasma insulin and blood tumor necrosis factor-α( TNF-α) were measured .The glucose tolerance test was performed .The insulin resistance index was calculated .The function of water decoction of Platycladus orientalis to reduce high blood glucose caused by diabetes was observed by these above indexes .RESULTS:Water decoction of Platycladus orientalis lowered the increasing rate of weight , hepatic index and lipid content of liver , reduced the blood content of TC , TG and IL-6, and elevated the blood HDL-C and ADP content caused by high-fat diet apparently (P<0.05).The effect of water decoction of Platycladus orientalis at high dose was more effective than that at low dose .Water decoction of Platycladus orientalis obviously alleviated the abnormity of glucose tole-rance test, reduced blood TNF-αand insulin levels, and decreased insulin resistance index caused by diabetes apparently (P<0.05).The effect of the drug at high dose was stronger than that at low dose .CONCLUSION:The water decoction of Platycladus orientalis dose-dependently reduces blood glucose caused by diabetes and blood lipids caused by hyperlipi -demia in the mice.The mechanism to reduce blood lipids may be related with elevating blood ADP content and reducing blood IL-6 content, and the mechanism to reduce blood glucose may be related with lowering blood TNF-αcontent.