Advances in imaging research of the central nervous system in painful diabetic neuropathy / 医学研究生学报

ABSTRACT

Painful diabetic neuropathy (PDN) seriously affects the patients′life quality, while the exact pathogenesis is un-known.Increasing number of evidences show that these patients have pathological changes of the central nervous system .Multimodal magnetic resonance imaging can noninvasively detect changes in the structure and function of the central nervous system , and become a new means to study the disease mechanisms .This article reviews the central mechanisms of PDN as well as multimodal magnetic reso -nance imaging findings that patients with PDN exist thalamic nerve dysfunction , increased thalamic blood flow , volume reduction of so-matosensory cortical gray matter , the default network and attention network destruction , and so on .