Genotoxicity of Sanqi Liver-protecting Capsules / 中国药师
China Pharmacist
;
(12): 1749-1752, 2017.
Artículo
en Chino
| WPRIM
| ID: wpr-658137
ABSTRACT
Objective:
To study the acute toxicity and genotoxicity of Sanqi liver-protecting capsules to evaluate the toxicological safety.Methods:
The mouse acute oral toxicity test, Ames test, micronucleus test of mouse bone marrow and mouse sperm shape ab-normality test were carried out for Sanqi liver-protecting capsules.Results:
The mouse acute oral maximum tolerance dose ( MTD) of Sanqi liver-protecting capsules was above 20 g·kg-1 in the mouse acute oral toxicity test, which showed a non-toxic substance. The results of Ames test, micronucleus test of mouse bone marrow and mouse sperm shape abnormality test were negative in all the groups.Conclusion:
Under the above experimental conditions,the genotoxicity of Sanqi liver-protecting capsules is not found out, therefore, the capsules are classified as a non-toxic drug.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
China Pharmacist
Año:
2017
Tipo del documento:
Artículo
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