An animal model using Eimeria live vaccine and to study coccidiosis protozoa pathogenesis / 대한수의학회지
Korean Journal of Veterinary Research
;
: 249-252, 2011.
Artículo
en Inglés
| WPRIM
| ID: wpr-65836
ABSTRACT
Cell culture systems for the protozoan Eimeria are not yet available. The present study was conducted to develop an animal model system by inoculating animals with a live Eimeria vaccine. This study was conducted on 3-day-old chickens (n = 20) pretreated with cyclophosphamide. The chickens were divided into 2 groups the control group (n = 10) and the inoculated group that received the live Eimeria vaccine (n = 10). During the study period, we compared the clinical signs, changes in body weight, and number of oocysts shed in the feces of the control and inoculated group. This study showed that oocyst shedding was significantly higher in the chickens inoculated with live Eimeria oocysts than in the control chickens. Moreover, body weight gain was lesser in the animals in the inoculated group than in the control animals. Fecal oocyst shedding was observed in the inoculated animals. On the basis of these findings, we suggest that live Eimeria vaccination with cyclophosphamide pretreatment may be used to obtain an effective animal model for studying protozoan infections. This animal study model may eliminate the need for a tedious continuous animal inoculation process every 6 months because the live coccidiosis vaccine contains live oocysts.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Infecciones por Protozoos
/
Peso Corporal
/
Pollos
/
Vacunación
/
Coccidiosis
/
Técnicas de Cultivo de Célula
/
Ciclofosfamida
/
Modelos Animales
/
Oocistos
/
Eimeria
Tipo de estudio:
Estudio de etiología
Límite:
Animales
Idioma:
Inglés
Revista:
Korean Journal of Veterinary Research
Año:
2011
Tipo del documento:
Artículo
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