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Development of an attenuated vaccine strain from a korean respiratory type infectious bronchitis virus / 대한수의학회지
Korean Journal of Veterinary Research ; : 193-201, 2011.
Artículo en Coreano | WPRIM | ID: wpr-65844
ABSTRACT
An attenuated vaccine strain AVR1/08 of Korean respiratory type of infectious bronchitis virus (IBV) was developed by 89th passages of IBV D85/06 strain in chicken eggs. The AVR1/08 strain had higher virus titer at least 20 times (10(1.3)) than the parent virus D85/06 by egg inoculation method. The AVR1/08 strain had a single point mutation (S to Y) at position 56 of spike protein of IBV compared to parent virus IBV D85/06 strain. The mutation was observed consistently at viruses after 47th passage in chicken eggs. The AVR1/08 strain showed no virulence even after 6 passages in chickens and all chickens inoculated induced anti-IBV antibody 14 days after vaccination. The AVR1/08 strain had broad protective efficacy against QX type Korean nephropathogenic virus (Q43/06 strain), KM91 type Korean nephropathogenic virus (KM91 strain) and Korean respiratory virus (D85/06 strain). In contrast, Massachusetts (Mass) type attenuated vaccine strain H120 showed protection of 37.5 to 50% against these three viruses. Our results indicate that the AVR1/08 strain has potential as an attenuated vaccine effective in controlling IBVs circulating in Korea.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Óvulo / Padres / Esguinces y Distensiones / Virus / Pollos / Massachusetts / Vacunación / Mutación Puntual / Virus de la Bronquitis Infecciosa / Carga Viral Límite: Humanos País/Región como asunto: America del Norte / Asia Idioma: Coreano Revista: Korean Journal of Veterinary Research Año: 2011 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Óvulo / Padres / Esguinces y Distensiones / Virus / Pollos / Massachusetts / Vacunación / Mutación Puntual / Virus de la Bronquitis Infecciosa / Carga Viral Límite: Humanos País/Región como asunto: America del Norte / Asia Idioma: Coreano Revista: Korean Journal of Veterinary Research Año: 2011 Tipo del documento: Artículo