Progress of cancer vaccines in treatment of human epidermal growth factor receptor 2 positive breast cancer / 肿瘤研究与临床

ABSTRACT

Human epidermal growth factor receptor 2 (HER-2) is overexpressed in approximately 30%of breast cancer patients. The monodonal antibodies of HER-2 have been proved to be effective in not only metastatic but also early stage HER-2 positive breast cancer since 1990S. With the development of cell biology, molecular biology and immunology, immunotherapy becomes a new treatment for breast cancer. Great improvement has been made in cancer vaccines targeting HER-2, including peptide vaccines, protein vaccines,cell vaccines,dendritic cell-associated vaccines and DNA vaccines.This paper reviews some studies and unsolved problems in cancer vaccines for HER-2 positive breast cancer.